2-甲基-3-硝基苯甲酸合成路线 （共 60 条）
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 20, p. 169
反应条件
sulfuric acid Heating;
参考文献
Tetrahedron Letters, , vol. 48, # 31 p. 5465 - 5469
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=60°C; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3350 - 3352
反应条件
in N,N-dimethyl-formamide 22 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 1 p. 249 - 253
反应条件
1: 1.) KHCO3 / 1.) DMF, 40 deg C, 2.) DMF, RT, 12 h 2: dimethylformamide / 12 h / 120 °C 3: H2 / 10 percent Pd/C / benzene / 12 h / 2844.31 Torr / Ambient temperature View Scheme
参考文献
Kruse, Lawrence I.
Heterocycles, 1981 , vol. 16, # 7 p. 1119 - 1124
反应条件
in N-methyl-acetamide
参考文献
SmithKline Beckman Corporation
Patent: US4394514 A1, 1983 ;
反应条件
1.1: 98 percent / H2 / Pd/C / ethanol / 20 °C 2.1: NaNO2; H2SO4 / H2O / 0 °C 2.2: 99 percent / aq. H2SO4 / Heating 3.1: 100 percent / hydrogen chloride / Heating 4.1: 72 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1: 100 percent / BH3 / tetrahydrofuran 2: 100 percent / SOCl2, pyridine 3: 99 percent / ethanol; H2O 4: 97 percent / H2SO4, HOAc / H2O 5: SOCl2 6: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h 7: 83 percent / BH3 / tetrahydrofuran / 1.) reflux, 1h, 2.) overnight 8: 1.) K, EtOH / 1.) Et2O, 10 min, 2.) Et2O, overnight 9: 80 percent / 2percent aq. NaOH, 30percent aq. H2O2 / 1 h / Ambient temperature 10: 78 percent / H2 / 5percent Pd/C / ethanol / 5 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 100 percent / BH3 / tetrahydrofuran 2: 100 percent / SOCl2, pyridine 3: 99 percent / ethanol; H2O 4: 97 percent / H2SO4, HOAc / H2O 5: SOCl2 6: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h 7: 83 percent / BH3 / tetrahydrofuran / 1.) reflux, 1h, 2.) overnight View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
