2-甲基-3-硝基苯甲酸合成路线 （共 60 条）
反应条件
1.1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / 5 h / 20 °C 2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C 3.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C 4.1: potassium acetate / chloroform / 12 h / 20 °C 4.2: 3 h / 65 °C View Scheme
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
WO 2012/118812 A2
参考文献
Jacobsen; Wierss
Chemische Berichte, 1883 , vol. 16, p. 1959
Chemische Berichte, 1884 , vol. 17, p. 164
参考文献
van Scherpenzeel
Recueil des Travaux Chimiques des Pays-Bas, 1901 , vol. 20, p. 169
反应条件
1: H2SO4 2: H2 / Pd-C / aq. ethanol; 2-methoxy-ethanol View Scheme
参考文献
Tetrahedron, , vol. 25, p. 4249 - 4256
反应条件
1: 100 percent / BH3 / tetrahydrofuran 2: 100 percent / SOCl2, pyridine 3: 99 percent / ethanol; H2O 4: 97 percent / H2SO4, HOAc / H2O View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
sodium hydroxide; sulfuric acid; acetic anhydride; magnesium sulfate; sodium nitrite; palladium monocarbide in pyridine; ethanol; ethyl acetate; toluene
参考文献
Japan Tobacco Inc.; Agouron Pharmaceuticals, Inc.
Patent: US6133461 A1, 2000 ;
反应条件
1: SOCl2 2: NaBH4 / tetrahydrofuran 3: SOCl2, pyridine View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / 5 h / 20 °C 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C View Scheme
参考文献
EPIZYME, INC.; EISAI RandD MANAGEMENT CO.LTD.; KUNTZ, Kevin, Wayne; HUANG, Kuan-chun; CHOI, Hyeong, Wook; SANDERS, Kristen; MATHIEU, Steven; CHANDA, Arani; FANG, Frank
Patent: WO2013/155317 A1, 2013 ;
反应条件
borane in tetrahydrofuran
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
in N,N-dimethyl-formamide
T=115°C; 24 h;
参考文献
Kruse, Lawrence I.
Heterocycles, 1981 , vol. 16, # 7 p. 1119 - 1124
