2-甲基-5-硝基苯甲酸合成路线 （共 42 条）
参考文献
Chemische Berichte, , vol. 17, p. 161
反应条件
1: H2 / PtO2 / ethanol 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Ashton, Michael J.; Brown, Thomas J.; Fenton, Garry; Halley, Frank; Harper, Mark F.; Lockey, Peter M.; Porter, Barry; Roach, Alan G.; Stuttle, Keith A. J.; Vicker, Nigel; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3343 - 3356
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 23°C; Combinatorial reaction / High throughput screening (HTS)Inert atmosphere;
参考文献
Ghosh, Arun K.; Takayama, Jun; Aubin, Yoann; Ratia, Kiira; Chaudhuri, Rima; Baez, Yahira; Sleeman, Katrina; Coughlin, Melissa; Nichols, Daniel B.; Mulhearn, Debbie C.; Prabhakar, Bellur S.; Baker, Susan C.; Johnson, Michael E.; Mesecar, Andrew D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5228 - 5240
反应条件
1: AcCl / Heating 2: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 20 h / Heating View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
borane; potassium carbonate in tetrahydrofuran; water
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C 2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C 2.2: 0.5 h / |Reflux 3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C 4.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3 h / 72 °C View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C 2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C 2.2: 0.5 h / |Reflux View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
potassium carbonate in N,N-dimethyl-formamide T=40°C; 1 h;
参考文献
Fujii, Naoaki; Haresco, Jose J.; Novak, Kathleen A. P.; Stokoe, David; Kuntz, Irwin D.; Guy, R. Kiplin
Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12074 - 12075
反应条件
thionyl chloride T=0°C; Reflux;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; PURDUE RESEARCH FOUNDATION
Patent: US2011/269834 A1, 2011 ;
Location in patent: Page/Page column 28-29 ;
参考文献
MERCK SHARP and DOHME LTD.
Patent: EP514133 A1, 1992 ;
EP 0514133 A1
