3-醛基吲哚-5-甲酸甲酯合成路线 （共 5 条）
反应条件
trichlorophosphate in water T=20°C; 2.25 h; Heating / reflux;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2006/276496 A1, 2006 ;
Location in patent: Page/Page column 62; 63 ;
US 20060276496 A1
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
tert.-butylhydroperoxide; Cl2Ru*(x)H2O; 2-oxo-3,3-dimethyl-butanoic acid in N-methyl-acetamide T=25°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Wu, Wenliang; Su, Weiping
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 11924 - 11927
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Reflux 2.1: trichlorophosphate / 0.08 h / 0 °C / Inert atmosphere 2.2: 1 h / 120 °C View Scheme
反应条件
1: With sodium tetrahydroborate in methanol
T=0 - 20°C; 0.5 h;
2: With water in ethyl acetate
参考文献
Astellas Pharma Inc.
Patent: EP1988076 A1, 2008 ;
Location in patent: Page/Page column 27 ;
