2-氟-4-羟基苯甲酸甲酯合成路线 （共 6 条）
反应条件
sulfuric acid T=90°C; 16 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2522657 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
1: in hexane; toluene 0.0833333 h; 2: With acetic acid in hexane; water; toluene 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
WO2007/3962 A2, ;
Page/Page column 22-23 ;
WO 2007/003962 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C;
参考文献
Asahi Kasei Pharma Corporation
Patent: EP2484668 A1, 2012 ;
Location in patent: Page/Page column 79 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.75 h;
参考文献
Woo, L. W. Lawrence; Wood, Paul M.; Bubert, Christian; Thomas, Mark P.; Purohit, Atul; Potter, Barry V. L.
ChemMedChem, 2013 , vol. 8, # 5 p. 779 - 799
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Wood, Paul M.; Bubert, Christian; Thomas, Mark P.; Purohit, Atul; Potter, Barry V. L.
ChemMedChem, 2013 , vol. 8, # 5 p. 779 - 799
