8-溴-3-甲基-[1,6]萘啶-2-羧酸合成路线 （共 7 条）
反应条件
bromine in acetic acid
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 6 p. 1693 - 1695
反应条件
1: 65 percent / tBuLi / tetrahydrofuran / -78 °C 2: 90 percent / TFA / CH2Cl2 3: 90 percent / aq. NaOH 4: 59 percent / Br2 / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 16 p. 3023 - 3025
反应条件
1: 90 percent / aq. NaOH 2: 59 percent / Br2 / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 16 p. 3023 - 3025
反应条件
1: 90 percent / TFA / CH2Cl2 2: 90 percent / aq. NaOH 3: 59 percent / Br2 / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 16 p. 3023 - 3025
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C; 16 h;
参考文献
Hanson, Gunnar J.; Ware, Roy W.; Barta, Thomas E.; Huang, He
Patent: US2006/30584 A1, 2006 ;
Location in patent: Page/Page column 34-35 ;
反应条件
hydrogenchloride in water
T=70°C; 2 h;
参考文献
D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.
Patent: US2008/242694 A1, 2008 ;
Location in patent: Page/Page column 46 ;
US 20080242694 A1
反应条件
1: With 1,1'-carbonyldiimidazole in dichloromethane
6 h;
2: With ammonia in 1,4-dioxane; methanol; dichloromethane
T=20°C; 12 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2380878 A1, 2011 ;
Location in patent: Page/Page column 28 ;
