1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 3: With ammonium chloride in tetrahydrofuran; hexane T=20°C; Further stages.;
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: 2,2,2-trifluoro-N-methoxy-N-methylacetamide in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: trifluoroacetyl fluoride in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
1: 1-bromo-3,5-dichloro-benzene With magnesium in tetrahydrofuran T=20°C; Reflux; 2: benzonitrile in tetrahydrofuran 48 h; Reflux; 3: With hydrogenchloride; water in tetrahydrofuran 4 h;
参考文献
TRANSITIONS OPTICAL, INC.
Patent: WO2012/82999 A1, 2012 ;
Location in patent: Page/Page column 39 ;
