2,3,4-三氟-5-硝基苯甲酸合成路线 （共 7 条）
反应条件
sulfuric acid; nitric acid 2.5 h;
参考文献
NOVARTIS PHARMA AG; AMGEN INC.; HUANG, Xizhong; PETERS, Malte; SCHUMACHER, Karl, Maria; CAO, Zhu, Alexander; GANSERT, Jennifer, Lorraine; CHANG, David, Dong, Eun; BELTRAN, Pedro
Patent: WO2013/142182 A2, 2013 ;
Location in patent: Page/Page column 21 ;
反应条件
sulfuric acid; nitric acid
反应条件
1: ammonium hydroxide / water / 2.5 h / 0 - 20 °C 2: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere View Scheme
反应条件
1: With ammonia in water T=0 - 20°C; 2.5 h; 2: With hydrogenchloride in water pH=0;
参考文献
US2004/116710 A1, ;
Page 6; 16 ;
US 20040116710 A1
反应条件
chloro-trimethyl-silane
T=10 - 30°C; 5 h; Heating / reflux;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2157 A2, 2007 ;
Location in patent: Page/Page column 69 ;
WO 2007/002157 A2
反应条件
1: With ammonia in 1-methyl-pyrrolidin-2-one; water
T=80 - 90°C; P=300.03 Torr; 3.25 h; in sealed reactor;
2: With acetic acid in 1-methyl-pyrrolidin-2-one; water
pH=6;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2157 A2, 2007 ;
Location in patent: Page/Page column 75 ;
WO 2007/002157 A2
反应条件
1: ammonium hydroxide / water / 2.5 h / 0 - 20 °C
2: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere
3: anhydrous xylene / 144 h / 140 °C / |Inert atmosphere
View Scheme
参考文献
NOVARTIS PHARMA AG; AMGEN INC.; HUANG, Xizhong; PETERS, Malte; SCHUMACHER, Karl, Maria; CAO, Zhu, Alexander; GANSERT, Jennifer, Lorraine; CHANG, David, Dong, Eun; BELTRAN, Pedro
Patent: WO2013/142182 A2, 2013 ;
