1-Boc-4-(4-甲酰苯基)哌嗪合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
ACHAOGEN, INC.
Patent: WO2008/154642 A2, 2008 ;
Location in patent: Page/Page column 155-156 ;
WO 2008/154642 A2
反应条件
diisobutylaluminium hydride in hexane; toluene T=50°C; 1.5 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 9 p. 1458 - 1469
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 14 h; Heating / reflux; 2: With potassium hydroxide in tetrahydrofuran; water
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
Location in patent: Paragraph 0522; 0523 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8721 - 8734,14
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8721 - 8734
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / |Reflux 2: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
反应条件
1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; oxygen / toluene / 12 h / 120 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Zhe; Gever, Joel R.; Rao, Satish; Widjaja, Kartika; Prusiner, Stanley B.; Silber, B. Michael
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 4 p. 397 - 401
