5-甲基异恶唑-3-羧酸甲酯合成路线 （共 9 条）
反应条件
sulfuric acid; hydroxylamine hydrochloride; sodium acetate 1.) water, reflux, 2 h, 2.) water, reflux, 3 h; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 11 p. 839 - 850
反应条件
1: 1-benzylhydrazine dihydrochloride With ammonium hydroxide; acetic acid in ethanol T=30°C; pH=5; 2: methyl-5-methyl-3-isoxazole carboxylate in ethanol
参考文献
Journal of Heterocyclic Chemistry, , vol. 46, # 5 p. 909 - 913
参考文献
Journal of Medicinal and Pharmaceutical Chemistry, , vol. 2, p. 133 - 145
US2908688 , ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-75 - 20°C; 2: With hydrogenchloride in water pH=1 - 2;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.
Patent: US2006/293329 A1, 2006 ;
Location in patent: Page/Page column 19 ;
参考文献
Freri
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 457,461
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 5.5 h;
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1550657 A1, 2005 ;
Location in patent: Page/Page column 81 ;
参考文献
Gardner,T.S. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 241 - 252
反应条件
bromine in chloroform
3 h; Heating / reflux;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2005/37271 A2, 2005 ;
Location in patent: Page/Page column 185 ;
WO 2005/037271 A2
反应条件
1: N2H4+H2O
2: aqueous HCl; NaNO2
View Scheme
参考文献
Freri
Gazzetta Chimica Italiana, 1932 , vol. 62, p. 457,461
