(1R,2s)-2-氨基-环戊烷羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 1 h;
参考文献
GILEAD SCIENCES, INC.; CAI, Zhenhon, R.; DU, Zhimin; JI, Mingzhe; JIN, Haolun; KIM, Choung, U.; LI, Jiayao; PHILLIPS, Barton, W.; PYUN, Hyung-jung; SAUGIER, Joseph, H.
Patent: WO2013/90929 A1, 2013 ;
Location in patent: Page/Page column 67; 68 ;
反应条件
1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere 2: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / Inert atmosphere 3: Acidic conditions View Scheme
参考文献
Evans, Caroline D.; Mahon, Mary F.; Andrews, Philip C.; Muir, James; Bull, Steven D.
Organic Letters, 2011 , vol. 13, # 23 p. 6276 - 6279
反应条件
1: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / Inert atmosphere 2: Acidic conditions View Scheme
参考文献
Evans, Caroline D.; Mahon, Mary F.; Andrews, Philip C.; Muir, James; Bull, Steven D.
Organic Letters, 2011 , vol. 13, # 23 p. 6276 - 6279
反应条件
1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere 2.2: 3 h / 20 °C / Inert atmosphere 3.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere 4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / Inert atmosphere 5.1: Acidic conditions View Scheme
参考文献
Evans, Caroline D.; Mahon, Mary F.; Andrews, Philip C.; Muir, James; Bull, Steven D.
Organic Letters, 2011 , vol. 13, # 23 p. 6276 - 6279
反应条件
1.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere 1.2: 3 h / 20 °C / Inert atmosphere 2.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere 3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / Inert atmosphere 4.1: Acidic conditions View Scheme
参考文献
Evans, Caroline D.; Mahon, Mary F.; Andrews, Philip C.; Muir, James; Bull, Steven D.
Organic Letters, 2011 , vol. 13, # 23 p. 6276 - 6279
反应条件
transaminase ATA-024; isopropylamine in aq. phosphate buffer; ethanol T=30°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Cuetos, Anibal; Lavandera, Ivan; Gotor, Vicente
Chemical Communications, 2013 , vol. 49, # 91 p. 10688 - 10690
反应条件
transaminase ATA-234; isopropylamine in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Cuetos, Anibal; Lavandera, Ivan; Gotor, Vicente
Chemical Communications, 2013 , vol. 49, # 91 p. 10688 - 10690
参考文献
Evans, Caroline D.; Mahon, Mary F.; Andrews, Philip C.; Muir, James; Bull, Steven D.
Organic Letters, 2011 , vol. 13, # 23 p. 6276 - 6279
参考文献
Kanerva, Liisa T.; Csomos, Peter; Sundholm, Oskari; Bernath, Gabor; Fueloep, Ferenc
Tetrahedron Asymmetry, 1996 , vol. 7, # 6 p. 1705 - 1716
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Forro, Eniko; Fueloep, Ferenc
Chemistry - A European Journal, 2007 , vol. 13, # 22 p. 6397 - 6401
