N-[叔丁氧羰基]-L-丙氨酰-L-丙氨酸甲酯合成路线 （共 21 条）
反应条件
1: 97 percent / 1.2 N HCl / acetic acid / 0.42 h 2: 85 percent / NEM, DCCI / CH2Cl2; dimethylformamide / 20 h / 0 °C 3: 85 percent / 1) 1 N NaOH / methanol / 2 h / Ambient temperature 4: H2 / 10percent Pd/C / methanol View Scheme
参考文献
Brueckner; Jung
1980 , vol. No. 1, p. 37 - 49
反应条件
1: 97 percent / 1.2 N HCl / acetic acid / 0.42 h 2: 85 percent / NEM, DCCI / CH2Cl2; dimethylformamide / 20 h / 0 °C 3: 85 percent / 1) 1 N NaOH / methanol / 2 h / Ambient temperature View Scheme
参考文献
Brueckner; Jung
1980 , vol. No. 1, p. 37 - 49
反应条件
triethylamine in tetrahydrofuran
T=20°C;
参考文献
Nowshuddin, Shaik; Ram Reddy
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 22 - 25
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide
T=0 - 20°C; Inert atmosphere;
参考文献
Xiao, Youli; Lee, Kent; Liu, Pinghua
Organic Letters, 2008 , vol. 10, # 24 p. 5521 - 5524
反应条件
tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) in dichloromethane
0.0833333 h;
参考文献
Roos; Bernabe; Hiemstra; Speckamp; Kaptein; Boesten
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1733 - 1740
反应条件
NMM in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Prabhakaran, Erode N.
Patent: US2010/228004 A1, 2010 ;
反应条件
triethylamine; dicyclohexyl-carbodiimide in dichloromethane
T=0 - 20°C;
参考文献
Monney, Angele; Nastri, Flavia; Albrecht, Martin
Dalton Transactions, 2013 , vol. 42, # 16 p. 5655 - 5660
反应条件
triethylamine in 1,4-dioxane; dichloromethane
T=0 - 20°C; 16 h;
参考文献
Radyukhin, V. A.; Kazakova, N. A.; Filippovich, E. I.; Evstigneeva, R. P.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 2 p. 432 - 440,377 - 384
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Rella, Maria Rosaria; Williard, Paul G.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 525 - 531
反应条件
Sm(III) chloride
T=50°C; 144 h; sealed tubeInert atmosphere;
参考文献
Gopinath, Pushparathinam; Nilaya, Surapaneni; Muraleedharan, Kannoth Manheri
Organic Letters, 2011 , vol. 13, # 8 p. 1932 - 1935
