N-[叔丁氧羰基]-L-丙氨酰-L-丙氨酸甲酯合成路线 （共 21 条）
反应条件
tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium(0) in dichloromethane
0.5 h; Ambient temperature; Yield given;
参考文献
Roos; Bernabe; Hiemstra; Speckamp; Kaptein; Boesten
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1733 - 1740
反应条件
1: 97.6 percent / aq. NaOH / tetrahydrofuran / 0 - 20 °C
2: 89 percent / K2CO3 / dimethylformamide
View Scheme
参考文献
Rella, Maria Rosaria; Williard, Paul G.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 525 - 531
参考文献
Bizzozero, Spartaco A.; Rovagnati, Bruno A.; Dutler, Hans
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1707 - 1719
反应条件
1: 97.6 percent / aq. NaOH / tetrahydrofuran / 0 - 20 °C
2: 89 percent / K2CO3 / dimethylformamide
View Scheme
参考文献
Rella, Maria Rosaria; Williard, Paul G.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 525 - 531
反应条件
tri-n-butyl-tin hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium(0)
1) CH2Cl2, room temp., 30 min., 2) CH2Cl2, room temp., 5 min.; Yield given. Multistep reaction;
参考文献
Roos, Eric C.; Bernabe, Pablo; Hiemstra, Henk; Speckamp, W. Nico
Tetrahedron Letters, 1991 , vol. 32, # 45 p. 6633 - 6636
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in acetonitrile
2 h;
参考文献
Nguyen, Dung Le; Dormoy, Jean-Robert; Castro, Bertrand; Prevot, Daniel
Tetrahedron, 1981 , vol. 37, # 24 p. 4229 - 4238
反应条件
1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 20 °C
2: triethylamine / tetrahydrofuran / 20 °C
View Scheme
参考文献
Nowshuddin, Shaik; Ram Reddy
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 22 - 25
反应条件
furan-2-carbonyl chloride; tris(dibenzylideneacetone)dipalladium (0); triphenylphosphine; zinc
1) THF, 35 deg C; Yield given. Multistep reaction;
参考文献
Dunn, Michael J.; Gomez, Sylvie; Jackson, Richard F. W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 13 p. 1639 - 1640
反应条件
chloro-trimethyl-silane; tris(dibenzylideneacetone)dipalladium (0); ethylene dibromide; triphenylphosphine; zinc
1) THF, 35 deg C; Yield given. Multistep reaction;
参考文献
Dunn, Michael J.; Gomez, Sylvie; Jackson, Richard F. W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 13 p. 1639 - 1640
反应条件
1: 100 percent / NH3 / methanol / 48 h / Ambient temperature
2: 100 percent / HCl / 1,2-dimethoxy-ethane / 1 h / Ambient temperature
View Scheme
参考文献
Bizzozero, Spartaco A.; Rovagnati, Bruno A.; Dutler, Hans
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1707 - 1719
