sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=80 - 100°C;

1: With tetrabutylammomium bromide; potassium carbonate in 1,4-dioxane; water T=0°C; 0.166667 h; Inert atmosphere; 2: With palladium diacetate T=70°C; Suzuki Coupling; 2 h; Inert atmosphere;

1: 2-bromo-α,α,α-trifluorotoluene With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: 4-chlorobenzaldehyde With potassium phosphate; C45H58ClNPPd in tetrahydrofuran; hexane; water T=40°C; Suzuki-Miyaura Coupling; 2 h; Inert atmosphere;

1: 1-iodo-2-(trifluoromethyl)benzene With copper; zinc in N,N-dimethyl-formamide T=80°C; 0.0333333 h; 2: 4-bromo-benzaldehyde With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=120°C; Negishi cross-coupling reaction; 0.0833333 h; Further stages.;

sodium tetrahydroborate in methanol T=20°C; 1 h;

potassium permanganate in 1,4-dioxane 2 h; Reflux;

sodium chlorite; sodium dihydrogenphosphate in water; tert-butyl alcohol T=20°C; 5.5 h;