2-环戊基-2-羟基苯乙酸甲酯合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Bodor, Nicholas S.
Patent: US2007/123557 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070123557 A1
反应条件
hydrogenchloride; acetic acid; nickel monoaluminide in toluene
参考文献
Institute of Pharmacology and Toxicology Academy of Military Sciences P.L.A.
Patent: US6028198 A1, 2000 ;
反应条件
1: cyclopentyl-bromide With iodine; magnesium in tetrahydrofuran T=0°C; RefluxInert atmosphere; 2: benzoyl-formic acid methyl ester in tetrahydrofuran T=10 - 20°C; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 16, # 11 p. 1754 - 1769
反应条件
sodium hydroxide in methanol; water T=20°C; Inert atmosphere;
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
sodium in n-heptane 3 h;
参考文献
Bodor, Nicholas S.
Patent: US2007/123557 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070123557 A1
反应条件
1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere 2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 19 h / 18 - 60 °C / |Inert atmosphere View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1.1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere 2.1: N,N-dimethyl-formamide / 20 h / 70 °C / |Inert atmosphere 2.2: 24 h / 70 °C / |Inert atmosphere View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1.1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere
2.1: N,N-dimethyl-formamide / 20 h / 70 °C / |Inert atmosphere
2.2: 24 h / 70 °C / |Inert atmosphere
3.1: toluene / 2 h / |Inert atmosphere
View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere
2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 18 h / 60 °C / |Inert atmosphere
View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
