1: 94 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 2: 98 percent / Bu4NF / tetrahydrofuran / 2 h / Ambient temperature 3: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme

1: 94 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 2: 98 percent / Bu4NF / tetrahydrofuran / 2 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11536633', constants.ctx, '0')">lithium borohydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=0 - 20&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / imidazole / dimethylformamide / 2 h / 20 &deg;C<br />2: 92 percent / LiBH₄ / diethyl ether / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / imidazole / dimethylformamide / 2 h / 20 &deg;C<br />2: 92 percent / LiBH₄ / diethyl ether / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 100 percent / Et₃N<br />2: 100 percent<br />3: 68 percent / LiBH₄ / diethyl ether / 1 h / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: pyridine; Et₃N / CH₂Cl₂ / 2 h / 20 &deg;C<br />2: imidazole / dimethylformamide / 11 h / 20 &deg;C<br />3: LiAlH₄ / tetrahydrofuran / 0.33 h / 20 &deg;C<br /> <br /> &nbsp;