3-甲基-5-苄氧基-2-(4-苄氧基苯基)-1H-吲哚合成路线 （共 12 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=120 - 150°C; Bischler indole synthesis; 4 h; Inert atmosphere;
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
反应条件
in dichloromethane; ethyl acetate; N,N-dimethyl-formamide
参考文献
American Home Products Corporation
Patent: US5880137 A1, 1999 ;
US 5880137 A
反应条件
acetic acid in ethanol T=75 - 80°C; Product distribution / selectivity;
参考文献
Divi's Laboratories Limited
Patent: EP2426105 A1, 2012 ;
Location in patent: Page/Page column 3-4 ;
反应条件
in isopropyl alcohol T=110 - 115°C; 5 h; Product distribution / selectivity;
参考文献
ZENTIVA A.S.
Patent: WO2008/98527 A1, 2008 ;
Location in patent: Page/Page column 5; 8; 9; 12 ;
反应条件
1: bromine / acetic acid / 3 h / 0 - 20 °C 2: triethylamine / N,N-dimethyl-formamide / 4 h / 120 - 150 °C / Inert atmosphere View Scheme
参考文献
Chemico-Biological Interactions, , vol. 197, # 1 p. 8 - 15
反应条件
1: potassium carbonate / acetone / 60 °C 2: bromine / acetic acid / 3 h / 0 - 20 °C 3: triethylamine / N,N-dimethyl-formamide / 4 h / 120 - 150 °C / Inert atmosphere View Scheme
参考文献
Chemico-Biological Interactions, , vol. 197, # 1 p. 8 - 15
反应条件
1: potassium carbonate / acetone / 60 °C 2: bromine / acetic acid / 3 h / 0 - 20 °C 3: triethylamine / N,N-dimethyl-formamide / 4 h / 120 - 150 °C / Inert atmosphere View Scheme
参考文献
Chemico-Biological Interactions, , vol. 197, # 1 p. 8 - 15
反应条件
1: 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: ethyl [p-(chloromethyl)phenoxy]acetate in N,N-dimethyl-formamide T=20°C; 18 h; Further stages.;
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
反应条件
in ethyl acetate; N,N-dimethyl-formamide
参考文献
Wyeth
Patent: EP1076558 B1, 2003 ;
反应条件
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 1.2: 59 percent / dimethylformamide / 18 h / 20 °C 2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 4.1: tetrahydrofuran 5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
