3-甲基-5-苄氧基-2-(4-苄氧基苯基)-1H-吲哚合成路线 （共 12 条）
反应条件
1: 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole With sodium hydride in N,N-dimethyl-formamide
T=0 - 5°C; Inert atmosphere;
2: 1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride in N,N-dimethyl-formamide
Inert atmosphere;
参考文献
Jirman, Josef; Richter, Jindrich
Patent: US2010/240888 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
1.2: 59 percent / dimethylformamide / 18 h / 20 °C
2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
4.1: tetrahydrofuran
View Scheme
参考文献
Lusin, Tina Trdan; Tomasic, Tihomir; Trontelj, Jurij; Mrhar, Ales; Peterlin-Masic, Lucija
Chemico-Biological Interactions, 2012 , vol. 197, # 1 p. 8 - 15
