5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚合成路线 （共 25 条）
反应条件
1.1: triethylamine / dichloromethane / 12 h / 20 °C
2.1: sodium tetrahydroborate / methanol / 1.25 h / 0 - 20 °C
3.1: phosphorus tribromide / dichloromethane / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 - -5 °C
4.2: 3 h / -5 - 0 °C
5.1: toluene / 12 h / 70 - 75 °C
View Scheme
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
反应条件
1.1: sodium tetrahydroborate / methanol / 1.25 h / 0 - 20 °C
2.1: phosphorus tribromide / dichloromethane / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 - -5 °C
3.2: 3 h / -5 - 0 °C
4.1: toluene / 12 h / 70 - 75 °C
View Scheme
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
反应条件
1.1: phosphorus tribromide / dichloromethane / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 - -5 °C
2.2: 3 h / -5 - 0 °C
3.1: toluene / 12 h / 70 - 75 °C
View Scheme
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 - -5 °C
1.2: 3 h / -5 - 0 °C
2.1: toluene / 12 h / 70 - 75 °C
View Scheme
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
