1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇合成路线 （共 32 条）
反应条件
hydrogen; 2.34 Pd/C in tetrahydrofuran; ethanol 5 h;
参考文献
Jirman, Josef; Richter, Jindrich
Patent: US2010/240888 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran T=5 - 10°C; 4 h;
参考文献
SANDOZ AG
Patent: US2012/253038 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
palladium hydroxide on carbon T=45 - 50°C; P=3677.86 - 5884.58 Torr;
参考文献
SANDOZ AG
Patent: US2012/253038 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
in toluene T=70 - 75°C; 12 h;
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
1.1: K2CO3 2.1: SOCl2 / tetrahydrofuran 3.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 3.2: 59 percent / dimethylformamide / 18 h / 20 °C 4.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 5.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 6.1: tetrahydrofuran 7.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: 51 percent / Et3N / dimethylformamide / Heating 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 1.2: 59 percent / dimethylformamide / 18 h / 20 °C 2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 4.1: tetrahydrofuran 5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: 51 percent / Et3N / dimethylformamide / Heating 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 1.2: 59 percent / dimethylformamide / 18 h / 20 °C 2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 4.1: tetrahydrofuran 5.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: SOCl2 / tetrahydrofuran 2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C 2.2: 59 percent / dimethylformamide / 18 h / 20 °C 3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C 4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C 5.1: tetrahydrofuran 6.1: H2 / Pd/C / ethanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1654 - 1657
