2,4-二氯-5-硝基苯甲酸合成路线 （共 14 条）
反应条件
1: H2SO4 View Scheme
参考文献
Loudon,J.D.; Smith,D.M.
Journal of the Chemical Society, 1964 , p. 2806 - 2810
反应条件
T=150°C; im Autoklaven;
参考文献
Villiger
Chemische Berichte, 1928 , vol. 61, p. 2598
反应条件
SnCl2*2H2O in ethanol T=20 - 70°C; 5.5 h;
参考文献
PRANA BIOTECHNOLOGY LIMITED; HUGGINS, Penelope, Jane; PARSONS, Jack, Gordon
Patent: WO2010/71944 A1, 2010 ;
Location in patent: Page/Page column 29-30 ;
WO 2010/071944 A1
反应条件
1: SOCl2 / 3 h / Heating 2: Et3N / toluene / 1 h / 90 °C 3: 94 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature 4: 92 percent / K2CO3 / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Cecchetti; Clementi; Cruciani; Fravolini; Pagella; Savino; Tabarrini
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 973 - 982
反应条件
sulfuric acid; nitric acid
T=0 - 20°C;
参考文献
Senthilkumar, Palaniappan; Dinakaran, Murugesan; Yogeeswari, Perumal; Sriram, Dharmarajan; China, Arnab; Nagaraja, Valakunja
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 345 - 358
反应条件
hydrogenchloride in water
参考文献
PRANA BIOTECHNOLOGY LIMITED; HUGGINS, Penelope, Jane; PARSONS, Jack, Gordon
Patent: WO2010/71944 A1, 2010 ;
Location in patent: Page/Page column 29-30 ;
WO 2010/071944 A1
反应条件
sulfuric acid; nitric acid
参考文献
Goldstein; Schaaf
Helvetica Chimica Acta, 1957 , vol. 40, p. 1187
反应条件
potassium permanganate
参考文献
Sacha; Patel
Journal of the Indian Chemical Society, 1957 , vol. 34, p. 821,824
反应条件
1: HNO3
2: aqueous KMnO4
View Scheme
参考文献
Sacha; Patel
Journal of the Indian Chemical Society, 1957 , vol. 34, p. 821,824
反应条件
folgend Behandeln mit Nitriersaeure bei 10grad;
参考文献
Villiger
Chemische Berichte, 1928 , vol. 61, p. 2598
