1-(3-羟基苯基)-哌嗪-4-羧酸叔丁酯合成路线 （共 7 条）
反应条件
in tetrahydrofuran T=20°C; 5 h;
参考文献
EXELIXIS, INC.
Patent: WO2005/117909 A2, 2005 ;
Location in patent: Page/Page column 118 ;
WO 2005/117909 A2
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Higgins, Guy A.; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3675 - 3678
参考文献
Karl Thomae
Patent: US5994356 A1, 1999 ;
反应条件
1: 100 percent / Pd(OAc)2; P(tBu)3; NaOtBu / toluene 2: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Higgins, Guy A.; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 100 percent / Pd(OAc)2; P(tBu)3; NaOtBu / toluene 2: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Higgins, Guy A.; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 80 percent / Et3N / CH2Cl2 2: 82 percent / PdCl2 (dppf); dppf; KOAc / dioxane View Scheme
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Higgins, Guy A.; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 64 percent / LAH / diethyl ether / Heating
2: 76 percent / Cs2CO3 / dimethylformamide / 18 h / 90 °C
View Scheme
参考文献
Lee-Dutra, Alice; Arienti, Kristen L.; Buzard, Daniel J.; Hack, Michael D.; Khatuya, Haripada; Desai, Pragnya J.; Nguyen, Steven; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Breitenbucher, J. Guy
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6043 - 6048
