6-苄基-1-噁-6-氮杂螺[2.5]辛烷合成路线 （共 12 条）
反应条件
tetrabutylammomium bromide; sodium hydroxide in toluene T=80°C; 8 h;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; Li, Yunfeng; Yang, Rifang; Zhang, Youzhi; Li, Yongzhen; Jin, Zengliang; Li, Peng; Yuan, Li; Yun, Liuhong; Zhao, Nan; Zhang, Cheng; Xu, Xiaodan; Zhao, Rusheng; Chen, Hongxia; Xue, Rui; Qin, Juanjuan; Wang, Zhenzhen; Yao, Jiazhi
Patent: US2013/231369 A1, 2013 ;
Location in patent: Paragraph 0104 ;
反应条件
1: trimethyl-oxo-sulfonium iodide With sodium hydride in dimethyl sulfoxide T=20 - 28°C; 1 h; 2: 1-Phenylmethyl-piperidin-4-one in dimethyl sulfoxide T=20°C; 1 h;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1568688 A1, 2005 ;
Location in patent: Page/Page column 37 ;
反应条件
tetrabutylammomium bromide; sodium hydroxide in toluene T=80°C;
参考文献
Weng, Zhiyong; Wei, Wei; Dong, Xiaowu; Hu, Yongzhou; Huang, Shufang; Liu, Tao; Xie, Xin
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 303 - 308
反应条件
1.1: methanol / 8.5 h / |Reflux 2.1: sodium methylate / toluene / 8 h / |Reflux 2.2: 6 h / |Reflux 3.1: sodium hydroxide; tetrabutylammomium bromide / toluene / 8 h / 80 °C View Scheme
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; Li, Yunfeng; Yang, Rifang; Zhang, Youzhi; Li, Yongzhen; Jin, Zengliang; Li, Peng; Yuan, Li; Yun, Liuhong; Zhao, Nan; Zhang, Cheng; Xu, Xiaodan; Zhao, Rusheng; Chen, Hongxia; Xue, Rui; Qin, Juanjuan; Wang, Zhenzhen; Yao, Jiazhi
Patent: US2013/231369 A1, 2013 ;
反应条件
1.1: sodium methylate / toluene / 8 h / |Reflux 1.2: 6 h / |Reflux 2.1: sodium hydroxide; tetrabutylammomium bromide / toluene / 8 h / 80 °C View Scheme
参考文献
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China; LI, Yunfeng; YANG, Rifang; ZHANG, Youzhi; LI, Yongzhen; JIN, Zengling; LI, Peng; YUAN, Li; YUN, Liuhong; ZHAO, Nan; ZHANG, Cheng; XU, Xiaodan; ZHAO, Rusheng; CHEN, Hongxia; XUE, Rui; QIN, Juanjuan; WANG, Zhenzhen; YAO, Jiazhi
Patent: EP2570410 A1, 2013 ;
反应条件
ammonium hydroxide in ethanol T=20°C; 9 h;
参考文献
SANOFI-AVENTIS
Patent: US2010/93668 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium hydroxide; sodium ethanolate Yield given. Multistep reaction;
参考文献
Satyamurthy, Nagichettiar; Berlin, K. Darrell; Powell, Douglas R.; Helm, Dick van der
Phosphorus and Sulfur and the Related Elements, 1984 , vol. 19, p. 137 - 154
反应条件
MgBr2(Et2O) in benzene T=40°C; 0.333333 h;
参考文献
Sheng, Rong; Hu, Yongzhou
Synthetic Communications, 2004 , vol. 34, # 19 p. 3529 - 3533
反应条件
1: aq. ammonia / ethanol / 9 h / 20 °C
2: 36.5 g / CH2Cl2 / 3 h / 20 °C
3: 97 percent / hydrazine hydrate / Pd/C / ethanol / 3 h / Heating
View Scheme
参考文献
Sonda, Shuji; Kawahara, Toshio; Katayama, Kenichi; Sato, Noriko; Asano, Kiyoshi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 9 p. 3295 - 3308
反应条件
1: methanol / Reflux
2: 5 Pd(II)/C(eggshell); hydrogen / methanol / Reflux
View Scheme
参考文献
Weng, Zhiyong; Wei, Wei; Dong, Xiaowu; Hu, Yongzhou; Huang, Shufang; Liu, Tao; Xie, Xin
Monatshefte fur Chemie, 2012 , vol. 143, # 2 p. 303 - 308
