5-氨基-1-苄基吡唑-4-甲酸乙酯合成路线 （共 6 条）
反应条件
1: 5-amino-1H-pyrazole-4-carboxylic acid ethyl ester With sodium hydride in acetonitrile 1 h; Cooling with ice; 2: benzyl chloride in acetonitrile T=20°C; 12 h;
参考文献
Baviskar, Ashish T.; Banerjee, Uttam C.; Gupta, Mukesh; Singh, Rajveer; Kumar, Sunil; Gupta, Manish K.; Kumar, Sanjeev; Raut, Satish K.; Khullar, Madhu; Singh, Sandeep; Kumar, Raj
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5782 - 5793
反应条件
triethylamine in ethanol 18 h; Heating / reflux;
参考文献
Jiang, May Xiao-Wu; Warshakoon, Namal C.; Miller, Marvin J.
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2824 - 2827
反应条件
in ethanol 12 h; Reflux;
参考文献
PROGENICS PHARMACEUTICALS, INC.; HAN, Amy, Qi; WANG, Eric; GAUSS, Carla; XIE, Walter; COBURN, Glen; DEMUYS, Jean-Marc
Patent: WO2010/118367 A2, 2010 ;
Location in patent: Page/Page column 92 ;
反应条件
1: 43 percent / Ac2O / Heating 2: 88 percent / Et3N / methanol / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 7 p. 2824 - 2827
反应条件
sodium hydride in acetonitrile T=20°C; 12 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 18 p. 5782 - 5793
反应条件
1: 73 percent / hydrazine monohydrate / ethanol / Heating 2: 82 percent / NaNO2; acetic acid / H2O / 0.5 h / 0 °C 3: 71 percent / xylene / Heating 4: H2 / Pd/C / methanol / 1.5 h / 20 °C View Scheme
参考文献
Chien, Tun-Cheng; Smaldone, Ronald A.; Townsend, Leroy B.
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4105 - 4108
