4-(2-N,N-二乙基氨基乙氧基l)-1-硝基苯合成路线 （共 18 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
WO2005/63239 A1, ;
Page/Page column 140 ;
WO 2005/063239 A1
反应条件
1: N,N-diethyl-2-aminoethanol With sodium hydride in tetrahydrofuran 0.5 h; 2: 4-fluoro-nitro-benzene in tetrahydrofuran T=-10 - 20°C; 2 h;
参考文献
US2004/6058 A1, ;
Page/Page column 90 ;
US 20040006058 A1
反应条件
potassium carbonate in water; xylene 2 h; Heating / reflux;
参考文献
EP1214318 B1, ;
Page/Page column 34 ;
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 3 h;
参考文献
WO2004/5282 A1, ;
Page 40 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Mitsunobu Displacement; 3 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 21 p. 9120 - 9135,16
Journal of Medicinal Chemistry, , vol. 55, # 21 p. 9120 - 9135
反应条件
1: 4-nitro-phenol With potassium carbonate in DMF (N,N-dimethyl-formamide) T=80°C; 0.0333333 h; 2: 2-diethylamino-1-chloroethane hydrochloride in DMF (N,N-dimethyl-formamide) T=90°C; 8 h;
参考文献
WO2004/39764 A1, ;
Page/Page column 83 ;
WO 2004/039764 A1
反应条件
potassium carbonate in anhydrous xylene; water; ethyl acetate
反应条件
methanesulfonic acid in tetrahydrofuran; methanol; methanolic ethyl acetate; chloroform; N,N-dimethyl-formamide; mineral oil
反应条件
ethanol; sodium ethanolate
参考文献
Bulletin de la Societe Chimique de France, , p. 1353,1358
反应条件
in N,N-dimethyl-formamide 20 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 26 p. 4770 - 4778
