2-[[4-(2-吡啶基)苯基]甲基]-肼羧酸-(1,1-二甲基)乙酯合成路线 （共 12 条）
反应条件
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C 2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 3: 25 percent / propan-2-ol / 24 h / Heating 4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 5: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme
参考文献
Xu, Zhongmin; Singh, Janak; Schwinden, Mark D.; Zheng, Bin; Kissick, Thomas P.; Patel, Bharat; Humora, Michael J.; Quiroz, Fernando; Dong, Lin; Hsieh, Dau-Ming; Heikes, James E.; Pudipeddi, Madhusudhan; Lindrud, Mark D.; Srivastava, Sushil K.; Kronenthal, David R.; Mueller, Richard H.
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 323 - 328
反应条件
hydrogenchloride in tetrahydrofuran; water
T=50°C; 3 h;
参考文献
Concert Pharmaceuticals Inc.
Patent: EP2003120 A1, 2008 ;
Location in patent: Page/Page column 36 ;
EP 2003120 A1
