Alpha-甲基-4-硝基苯乙酸合成路线 （共 24 条）
反应条件
1: concd. H2SO4 / 3 h / Heating
2: 94 percent / H2 / 5percent Pd/C / ethanol / 760 Torr
3: 160 - 170 °C
4: 78 percent / 10percent NaOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Hino; Nakamura; Nagai; Uno; Nishimura
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 222 - 226
反应条件
sulfuric acid
T=20°C; 15 h; Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 62; 64; 65-66 ;
US 20090156590 A1
反应条件
sulfuric acid in ethanol; water; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6004984 A1, 1999 ;
US 6004984 A
反应条件
sodium chloride; sodium hydrogencarbonate in hydrochloric acid-ethanol
参考文献
Nippon Shinyaku Company, Limited; Mitsubishi Chemical Industries Limited
Patent: US4720506 A1, 1988 ;
