4-(4-哌啶氧基)苯甲醛合成路线 （共 5 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane
T=20°C; Mitsunobu reaction;
参考文献
Neff, Danielle K.; Lee-Dutra, Alice; Blevitt, Jonathan M.; Axe, Frank U.; Hack, Michael D.; Buma, Johnathan C.; Rynberg, Raymond; Brunmark, Anders; Karlsson, Lars; Breitenbucher, J. Guy
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6467 - 6471
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 25°C; 4 h;
参考文献
Ma, Liang; Xie, Caifeng; Ran, Yan; Liang, Xiaolin; Huang, Li; Pei, Heying; Chen, Jinying; Liu, Juan; Sang, Yun; Lai, Huijun; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9958 - 9972
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C
2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 25 °C
View Scheme
参考文献
Ma, Liang; Xie, Caifeng; Ran, Yan; Liang, Xiaolin; Huang, Li; Pei, Heying; Chen, Jinying; Liu, Juan; Sang, Yun; Lai, Huijun; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9958 - 9972
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C
2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 25 °C
View Scheme
参考文献
Ma, Liang; Xie, Caifeng; Ran, Yan; Liang, Xiaolin; Huang, Li; Pei, Heying; Chen, Jinying; Liu, Juan; Sang, Yun; Lai, Huijun; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9958 - 9972
反应条件
1: pyridine / 6.1 h / 0 - 25 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C
3: trifluoroacetic acid / dichloromethane / 4 h / 0 - 25 °C
View Scheme
参考文献
Ma, Liang; Xie, Caifeng; Ran, Yan; Liang, Xiaolin; Huang, Li; Pei, Heying; Chen, Jinying; Liu, Juan; Sang, Yun; Lai, Huijun; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9958 - 9972
