1-(吡啶-2-基)哌啶-4-醇合成路线 （共 7 条）
反应条件
triethylamine in methanol T=150°C; 1 h; Microwaves;
参考文献
WO2011/86125 A1, ;
Page/Page column 36; 37 ;
WO 2011/086125 A1
反应条件
sodium tetrahydroborate in methanol T=0 - 20°C;
参考文献
Presset, Marc; Fleury-Bregeot, Nicolas; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A.
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4615 - 4619
反应条件
pyridine T=155°C; 18 h;
参考文献
WO2008/62276 A2, ;
Page/Page column 63 ;
WO 2008/062276 A2
参考文献
Lohray; Bhushan, Vidya; Reddy, A. Sekar; Rao, P. Bheema; Reddy, N. Jaipal; Harikishore; Haritha; Vikramadityan, Reeba K.; Chakrabarti, Ranjan; Rajagopalan; Katneni
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2569 - 2581
反应条件
1: PEPPSITM-IPr; potassium tert-butylate / ethylene glycol dimethyl ether / 24 h / 20 °C / |Inert atmosphere 2: toluene-4-sulfonic acid / water; acetone / 1 h / 150 °C / |Microwave irradiation; |Sealed tube 3: sodium tetrahydroborate / methanol / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 9 p. 4615 - 4619
反应条件
1: toluene-4-sulfonic acid / water; acetone / 1 h / 150 °C / |Microwave irradiation; |Sealed tube 2: sodium tetrahydroborate / methanol / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 9 p. 4615 - 4619
反应条件
1: PEPPSITM-IPr; potassium tert-butylate / ethylene glycol dimethyl ether / 24 h / 20 °C / |Inert atmosphere 2: toluene-4-sulfonic acid / water; acetone / 1 h / 150 °C / |Microwave irradiation; |Sealed tube 3: sodium tetrahydroborate / methanol / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 9 p. 4615 - 4619
