6-溴-3-乙基-1H-吲唑合成路线 （共 8 条）
反应条件
hydrazine hydrate in dimethyl sulfoxide T=130°C; 22 h;
参考文献
Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd.
Patent: US2011/118257 A1, 2011 ;
Location in patent: Page/Page column 98 ;
反应条件
sodium hydroxide in methanol; water; ethyl acetate; Petroleum ether 0.5 h; Heating / reflux;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: US2008/200471 A1, 2008 ;
Location in patent: Page/Page column 41; 42 ;
US 20080200471 A1
反应条件
potassium acetate; sodium nitrite in methanol; diethyl ether; chloroform; water
参考文献
Pfizer Inc
Patent: US6262040 B1, 2001 ;
US 6262040 B1
反应条件
hydrogenchloride; potassium acetate; sodium nitrite in methanol; diethyl ether; chloroform; water
参考文献
Pfizer Inc
Patent: US6211222 B1, 2001 ;
US 6211222 B1
反应条件
hydrogenchloride; potassium acetate; sodium nitrite in chloroform; water
参考文献
Pfizer Inc
Patent: US6040329 A1, 2000 ;
US 6040329 A
反应条件
potassium acetate; sodium nitrite in chloroform; water
参考文献
Pfizer Inc
Patent: US6127398 A1, 2000 ;
US 6127398 A
反应条件
1: diethyl ether / 12 h / 20 °C / Cooling with ice 2: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C 3: hydrazine hydrate / dimethyl sulfoxide / 22 h / 130 °C View Scheme
反应条件
1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C 2: hydrazine hydrate / dimethyl sulfoxide / 22 h / 130 °C View Scheme
