1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 15 h 2: 1.) KOH, 2.) H2 / 2.) 10 percent Pd/C / 1.) water, 0 deg C - RT, 2.) water, 23 h 3: 11.0 g / N-methylmorpholine, HOBT*H2O, EDC*HCl / dimethylformamide / 1.) from 0 deg C to RT, 2.) RT, 4 h View Scheme