7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮合成路线 （共 22 条）
反应条件
1: hydrogen / palladium on activated carbon / methanol 2: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 48, # 11 p. 829 - 843
反应条件
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 2.1: formamide / 20 - 100 °C 2.2: 78 percent / 7 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
反应条件
1.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 2.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 3.1: formamide / 20 - 100 °C 3.2: 78 percent / 7 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
反应条件
1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 5.1: formamide / 20 - 100 °C 5.2: 78 percent / 7 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
反应条件
1.1: 349 g / acetic anhydride / 3 h / 110 °C 2.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 2.1: 349 g / acetic anhydride / 3 h / 110 °C 3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C 2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating 3: 54 percent / LiCl / dimethylformamide / 15 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
