2-氧代吲哚-5-甲酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon T=45 - 115°C; P=2068.65 - 2585.81 Torr; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/71524 A2, 2009 ;
Location in patent: Page/Page column 15; 5 ;
反应条件
triethylamine; palladium diacetate in methanol; hexane; dimethyl sulfoxide; ethyl acetate
参考文献
Sugen, Inc.
Patent: US6147106 A1, 2000 ;
US 6147106 A
反应条件
triethylamine; 1,3-bis-(diphenylphosphino)propane in methanol; dimethyl sulfoxide 24 h; Heating / reflux;
参考文献
Sugen, Inc.
Patent: US6350754 B2, 2002 ;
Location in patent: Page column 23 ;
反应条件
1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate in methanol; dimethyl sulfoxide 24 h; Heating / reflux;
参考文献
Sugen, Inc.
Patent: US6878733 B1, 2005 ;
Location in patent: Page/Page column 171; 219 ;
US 6878733 B1
反应条件
acetic acid; zinc T=20°C; 2 h;
参考文献
Bramson; Holmes; Hunter; Lackey; Lovejoy; Luzzio; Montana; Rocque; Rusnak; Shewchuk; Veal; Corona; Walker; Kuyper; Davis; Dickerson; Edelstein; Frye; Gampe Jr.; Harris; Hassell
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4339 - 4358
反应条件
1.1: sulfuryl chloride / CH2Cl2 / 0.5 h / -70 °C 1.2: proton sponge / CH2Cl2 / -70 °C 1.3: 42 percent / TEA / CH2Cl2 / -70 - 20 °C 2.1: 99 percent / Zn; AcOH / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4339 - 4358
反应条件
aluminium trichloride in N,N-dimethyl-formamide Acylation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 3 p. 223 - 226
反应条件
sodium hydroxide in methanol; water
参考文献
Sugen, Inc.
Patent: US6147106 A1, 2000 ;
US 6147106 A
