2-氧代吲哚啉-5-磺酰氯合成路线 （共 8 条）
反应条件
chlorosulfonic acid T=70°C; 1.58333 h; Cooliing with ice;
参考文献
THE JOHNS HOPKINS UNIVERSITY; THE SCRIPPS RESEARCH INSTITUTE; ZACK, Donald, Jeffrey; BANNISTER, Thomas; VOJKOVSKY, Tomas; YANG, Zhiyong; BERLINICKE, Cynthia
Patent: WO2011/119777 A2, 2011 ;
Location in patent: Page/Page column 26 ;
WO 2011/119777 A2
反应条件
1: T=50 - 60°C; 12 h; 2: in dichloromethane
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2004/16619 A1, 2004 ;
Location in patent: Page 25 ;
WO 2004/016619 A1
反应条件
hydrogenchloride; sodium hydroxide in methanol; dimethyl amine
参考文献
Tang, Peng Cho; Harris, G. Davis; Li, Xiaoyuan
Patent: US2002/52369 A1, 2002 ;
US 20020052369 A1
反应条件
in methanol T=20°C; 2 h;
参考文献
SUGEN Inc.
Patent: US2004/204407 A1, 2004 ;
Location in patent: Page/Page column 29 ;
US 20040204407 A1
反应条件
ammonia in methanol T=20°C;
参考文献
US2004/186160 A1, ;
Page/Page column 21 ;
US 20040186160 A1
反应条件
in ethanol; dichloromethane
反应条件
ammonium hydroxide in ethanol
反应条件
chlorosulfonic acid; ammonium hydroxide in ethanol
参考文献
US2002/52369 A1, ;
US 20020052369 A1
