BOC-1-氨基-环辛烷羧酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=25°C; 18 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
PURDUE PHARMA L.P.; SHIONOGI and CO., LTD.
Patent: WO2009/27820 A2, 2009 ;
Location in patent: Page/Page column 276-278 ;
WO 2009/027820 A2
反应条件
1: ammonium carbonate / aq. ethanol / 55 - 60 °C 2: aq. NaOH / 72 h / Heating 3: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
1: aq. NaOH / 72 h / Heating 2: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
sodium hydroxide in 1,4-dioxane 12 h; Ambient temperature;
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
