3-[(羟基氨基)脒甲基]-苯甲酸合成路线 （共 6 条）
反应条件
hydroxylamine hydrochloride; potassium hydroxide in ethanol 18.5 h; Reflux;
参考文献
Girnys, Elizabeth A.; Porter, Vanessa R.; Mosberg, Henry I.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7425 - 7434
参考文献
Chemische Berichte, , vol. 20, p. 521
反应条件
pyridine T=0 - 50°C; 3 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; BALOGLU, Erkan
Patent: WO2013/6408 A1, 2013 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
1.1: acetic anhydride; acetic acid / water / 14 h / 118 °C 2.1: sulfuric acid / 18 h / Reflux 3.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C 3.2: pH 7 4.1: phosphorus tribromide / toluene / 3 h / 20 - 35 °C View Scheme
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Patent: US2011/269756 A1, 2011 ;
反应条件
1.1: acetic anhydride; acetic acid / water / 14 h / 118 °C
2.1: sulfuric acid / 18 h / Reflux
3.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C
3.2: pH 7
View Scheme
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Patent: US2011/269756 A1, 2011 ;
反应条件
1: With palladium 10 on activated carbon; hydrogen in water
T=50°C; P=2585.81 Torr; 20 h;
2: With hydrogenchloride in water
参考文献
Girnys, Elizabeth A.; Porter, Vanessa R.; Mosberg, Henry I.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7425 - 7434
