5-氨基-3,4-二甲基异唑合成路线 （共 58 条）
反应条件
1: (i) NaNO2, aq. HCl, (ii) /BRN= 108546/
2: <PhCH2NEt3>Cl, aq. Na2CO3 / benzene / 1 h / 50 °C
View Scheme
参考文献
Sir,C. et al.
Helvetica Chimica Acta, 1979 , vol. 62, p. 1570 - 1585
反应条件
tert.-butylnitrite
2 h; Irradiation;
参考文献
Julliard,M. et al.
Helvetica Chimica Acta, 1978 , vol. 61, p. 2941 - 2948
反应条件
hydrogenchloride
0.5 h; Ambient temperature;
参考文献
Longhi; De Bertorello
Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 8 p. 754 - 757
反应条件
1: in 1,2-dichloro-ethane
T=50°C; 36 h; PS-carbodiimide resin;
2: in 1,2-dichloro-ethane
T=20°C; 24 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/41773 A2, 2006 ;
Location in patent: Page/Page column 370-371 ;
WO 2006/041773 A2
反应条件
2: palladium/charcoal; methanol / Hydrogenation
View Scheme
参考文献
Okuda et al.
Ann. Pr. GifuChem.Abstr., Coll. Pharm. Nr. 5 <1955> 29, 32 1956 , p. 14865
反应条件
tert.-butylnitrite
2 h; Irradiation;
参考文献
Julliard,M. et al.
Helvetica Chimica Acta, 1978 , vol. 61, p. 2941 - 2948
反应条件
2: LiAlH4
3: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Kano; Makizumi
Yakugaku Zasshi, 1956 , vol. 76, p. 1311,1312
Chem.Abstr., 1957 , p. 4357
参考文献
Perlovich, German L.; Ryzhakov, Alex M.; Tkachev, Valery V.; Hansen, Lars Kr.; Raevsky, Oleg A.
Crystal Growth and Design, 2013 , vol. 13, # 9 p. 4002 - 4016
参考文献
Yamada; Kowaki
Yakugaku Zasshi, 1951 , vol. 71, p. 1356,1358
Chem.Abstr., 1952 , p. 8036
参考文献
Kano; Makisumi
Pharmaceutical Bulletin, 1955 , vol. 3, p. 270,272
