2-氨基-4-氯苯并噻唑合成路线 （共 28 条）
反应条件
benzenesulfonyl chloride in pyridine
参考文献
Lacova, Margita; Nga, Nguyen Thi
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 4 p. 1006 - 1014
反应条件
1: aq. NaOH / 24 h / Heating
2: 60 percent / NaOH / ethanol / 4 h / Heating
View Scheme
参考文献
Gupta; Ojha; Kumar
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1325 - 1327
反应条件
1: aq. NaOH / 24 h / Heating
2: 65 percent / NaOH / ethanol / 4 h / Heating
View Scheme
参考文献
Gupta; Ojha; Kumar
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1325 - 1327
反应条件
triethylamine in tetrahydrofuran
4 h; Ambient temperature;
参考文献
Glennon; Gaines; Rogers
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 766 - 769
反应条件
1: 81 percent / NEt3 / tetrahydrofuran / 4 h / Ambient temperature
2: 59 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Glennon; Gaines; Rogers
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 766 - 769
反应条件
triethylamine in benzene
3 h; Heating;
参考文献
Merchan; Garin; Melendez; Tejero
Synthesis, 1983 , vol. No. 2, p. 154 - 156
反应条件
sodium hydroxide
Heating;
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Takahashi, Kaoru; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 675 - 687
反应条件
hydrogenchloride; hydrazine hydrate
T=150°C; 3 h; Inert atmosphere;
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
Location in patent: Page/Page column 28; 29 ;
