3-氨基-5-氰基苯甲酸甲酯合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol T=20°C; 4 h;
参考文献
Hutchison Medipharma Enterprises Limited
Patent: US2009/118292 A1, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1: SO2(NH2)2; SOCl2 / tetrahydrothiophene 1,1-dioxide / 42 h / Heating 2: H2 / Pd/C / methanol View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
sodium hydroxide; sodium hydrogencarbonate in methanol
参考文献
Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik
Patent: US2003/55085 A1, 2003 ;
US 20030055085 A1
反应条件
1: 64 percent / H2 / PtO2 / methanol / 0.5 h / 1551.4 Torr 2: 11 percent / Et3N, HgCl2 / dimethylformamide / 1.) 5 deg C, 0.5 h, 2.) RT, 18 h View Scheme
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
反应条件
triethylamine; mercury dichloride in N,N-dimethyl-formamide 1.) 5 deg C, 0.5 h, 2.) RT, 18 h;
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
反应条件
1: trichlorophosphate / 1,2-dichloro-ethane / 3 h / Reflux 2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
