[1-[(2,6-二氟苯基)甲基]-4-甲基苯并咪唑-2-基]甲醇合成路线 （共 4 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
0.5 h; Ambient temperature;
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US6369235 B1, 2002 ;
Location in patent: Example 40 ;
反应条件
1: 84 percent / pyridine / 4 h / Ambient temperature
2: 93 percent / NaH / tetrahydrofuran / 4 h
3: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
参考文献
Roth, Thomas; Morningstar, Marshall L.; Boyer, Paul L.; Hughes, Stephen H.; Buckheit Jr., Robert W.; Michejda, Christopher J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4199 - 4207
反应条件
1: 93 percent / NaH / tetrahydrofuran / 4 h
2: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
参考文献
Roth, Thomas; Morningstar, Marshall L.; Boyer, Paul L.; Hughes, Stephen H.; Buckheit Jr., Robert W.; Michejda, Christopher J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4199 - 4207
反应条件
1: 84 percent / aq. HCl / 2 h / Heating
2: 84 percent / pyridine / 4 h / Ambient temperature
3: 93 percent / NaH / tetrahydrofuran / 4 h
4: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
参考文献
Roth, Thomas; Morningstar, Marshall L.; Boyer, Paul L.; Hughes, Stephen H.; Buckheit Jr., Robert W.; Michejda, Christopher J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4199 - 4207
