2,5-二氢-2,5-二甲氧基糠基醇合成路线 （共 5 条）
反应条件
1: 84.4 percent / HCOOH / methanol 2: 82 percent / Br2; Et3N / CH2Cl2 / 2 h / 20 °C 3: CF3COOH / 2 h / Heating View Scheme
参考文献
Liu, Zu D.; Khodr, Hicham H.; Liu, Ding Y.; Lu, Shu L.; Hider, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 23 p. 4814 - 4823
反应条件
sulfuric acid 0.5 h; Ambient temperature;
参考文献
Bennett, Mandy; Gill, G. Byron; Pattenden, Gerald; Shuker, Anthony J.; Stapleton, Alan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 4 p. 929 - 937
反应条件
1: 89.5 percent / H2SO4 / H2O / 4 h / 20 °C
2: 67 percent / NaOAc / tetrahydrofuran / 18 h / 0 - 20 °C
3: 82 percent / SnCl4 / 1,2-dichloro-ethane; CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Caddick; Khan; Frost; Smith; Cheung; Pairaudeau
Tetrahedron, 2000 , vol. 56, # 45 p. 8953 - 8958
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 5 h;
参考文献
Aso, Mariko; Usui, Kazuteru; Fukuda, Mitsuhiro; Kakihara, Yoshie; Goromaru, Tsuyoshi; Suemune, Hiroshi
Organic Letters, 2006 , vol. 8, # 15 p. 3183 - 3186
反应条件
formic acid in methanol
hydrolysis; ring expansion;
参考文献
Liu, Zu D.; Khodr, Hicham H.; Liu, Ding Y.; Lu, Shu L.; Hider, Robert C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 23 p. 4814 - 4823
