3,5-二溴-2,2,6,6-四甲基-4-哌啶酮氢溴酸盐合成路线 （共 11 条）
反应条件
bromine in acetic acid
参考文献
Groesbeek, M.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1995 , vol. 114, # 9/10 p. 403 - 409
反应条件
1: 70 percent / H2O / 3 h / 25 °C 2: 70 percent / benzene / 5 h / Heating View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
反应条件
1: K2CO3 / methanol; H2O / 3 h / 25 °C 2: H2 / 10percent Pd/C / CHCl3 / 25 °C / 760 Torr 3: 55 percent / EDTA-Na2, Na2WO4*2HCl, aq. H2O2 / methanol / 72 h / 20 °C View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
反应条件
1: 70 percent / H2O / 3 h / 25 °C 2: 93 percent / diethyl ether; tetrahydrofuran / 48 h / 25 °C 3: 40 percent / triethylamine (TEA) / toluene / 5 h / Heating 4: 63 percent / EDTA-Na2, Na2WO4*2HCl, aq. H2O2 / methanol / 72 h / 20 °C View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
反应条件
1: 70 percent / H2O / 3 h / 25 °C 2: p-toluenesulfonic acid / toluene / 16 h / Heating 3: NaBH4 / ethanol / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 7 p. 1138 - 1152
反应条件
ammonium hydroxide 2 h;
参考文献
Groesbeek, M.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1995 , vol. 114, # 9/10 p. 403 - 409
反应条件
1: Et3N / H2O / 12 h / 20 - 50 °C
2: 76.1 percent / H2O2; disodium tungstate dihydrate; disodium ethylenediaminetetraacetate dihydrate / H2O / 5 h / 20 °C
3: 88 percent / DIBAL / diethyl ether; hexane / 0.08 h / -78 °C
View Scheme
参考文献
Stork, Sebastian W.; Makinen, Marvin W.
Synthesis, 1999 , # 8 p. 1309 - 1312
反应条件
3-chloro-benzenecarboperoxoic acid in diethyl ether
参考文献
Brik, M. E.
Synthetic Communications, 1990 , vol. 20, # 4 p. 597 - 601
反应条件
1: 70 percent / H2O / 3 h / 25 °C
2: 93 percent / diethyl ether; tetrahydrofuran / 48 h / 25 °C
3: 40 percent / triethylamine (TEA) / toluene / 5 h / Heating
View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
反应条件
1: 70 percent / H2O / 3 h / 25 °C
2: 94 percent / diethyl ether; tetrahydrofuran / 48 h / 25 °C
View Scheme
参考文献
Hankovszky; Hideg; Bodi; Frank
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1138 - 1152
