1-乙酰氨基-3,5-二甲基金刚烷合成路线 （共 15 条）
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62472 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
参考文献
Stepanov,F.N.; Srebrodol'skii,Yu.T.
Zhurnal Organicheskoi Khimii, 1966 , vol. 2, # 9 p. 1612 - 1615,1590 - 1592
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62472 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium hydroxide in polyethylene glycol-400 T=170 - 180°C; 2 - 3 h;
参考文献
SAIRAM ORGANICS PVT. LTD.; PHARMACEUTICAL SOLUTIONS FZCO
Patent: WO2009/153806 A2, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62472 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
