2-氨基-4-氯-5-碘苯甲酸甲酯合成路线 （共 4 条）
反应条件
iodine; silver sulphate in ethanol T=20°C; 0.75 h;
参考文献
Elmore, Charles S.; Dean, Dennis C.; DeVita, Robert J.; Melillo, David G.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 10 p. 993 - 1000
反应条件
1: 93 percent / 1,2-dichloro-ethane / 3 h / 80 °C 2: 74 percent / Et3N; (PPh3)2PdCl2 / dimethylformamide / 16 h / 80 °C / 760.05 Torr View Scheme
参考文献
DeVita; Walsh; Young; Jiang; Ujjainwalla; Toupence; Parikh; Huang; Fair; Goulet; Wyvratt; Lo; Ren; Yudkovitz; Yang; Cheng; Cui; Mount; Rohrer; Schaeffer; Rhodes; Drisko; McGowan; MacIntyre; Vincent; Carlin; Cameron; Smith
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 917 - 922
反应条件
1: 88 percent / 1,2-dichloro-ethane / 4 h / Heating
2: 96 percent / LiN(SiMe3)2 / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
sodium hydroxide in methanol; water
T=70 - 80°C; 4 h;
参考文献
CHIRON CORPORATION
Patent: WO2004/18419 A2, 2004 ;
Location in patent: Page 266 ;
