(S)-2-(4’-溴联苯-4-磺酰胺)-3-甲基丁酸合成路线 （共 4 条）
反应条件
methoxybenzene; trifluoroacetic acid
T=20°C; Hydrolysis; 4 h;
参考文献
O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166
反应条件
1: ClSO3H / CHCl3 / 4 h / 20 °C
2: SOCl2 / dimethylformamide / 4 h / Heating
3: 95 percent / Et3N / tetrahydrofuran; H2O / 0.75 h / 20 °C
4: 67 percent / TFA; anisole / 4 h / 20 °C
View Scheme
参考文献
O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166
反应条件
1: 95 percent / Et3N / tetrahydrofuran; H2O / 0.75 h / 20 °C
2: 67 percent / TFA; anisole / 4 h / 20 °C
View Scheme
参考文献
O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166
反应条件
1: SOCl2 / dimethylformamide / 4 h / Heating
2: 95 percent / Et3N / tetrahydrofuran; H2O / 0.75 h / 20 °C
3: 67 percent / TFA; anisole / 4 h / 20 °C
View Scheme
参考文献
O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166
