1-(3-甲基-1,2-恶唑-5-基)丙酮合成路线 （共 6 条）
反应条件
ammonium acetate; n-butyllithium in tetrahydrofuran; diethyl ether; hexane
参考文献
Baxter, Andrew; Brough, Stephen; Faull, Alan; Johnstone, Craig; McInally, Thomas
Patent: US2002/107252 A1, 2002 ;
反应条件
1: With iron; acetic acid in methanol T=60°C; 1 h; Heating / reflux; 2: T=60°C; 0.333333 h;
参考文献
Nippon Soda Co., Ltd.
Patent: US6359143 B1, 2002 ;
Location in patent: Page column 14 ;
反应条件
1: 3,5-dimethyl-isoxazole With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 0.5 h; Cooling with acetone-dry ice; 2: N,N-dimethyl acetamide in tetrahydrofuran; hexane T=-65 - -60°C; 1 h;
参考文献
Nippon Soda Co., Ltd.
Patent: US6359143 B1, 2002 ;
Location in patent: Page column 13 ;
反应条件
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C 1.2: 60 h / 20 °C 2.1: methylmagnesium bromide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; TAYLOR, Alexander, M.; VASWANI, Rishi, G.
Patent: WO2013/184878 A1, 2013 ;
反应条件
lithium diisopropyl amide 1.) THF, hexane, -90 deg C, 30 min, 2.) THF, hexane, from -90 deg C to RT, 1 h; Yield given. Multistep reaction;
参考文献
Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola
Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327
反应条件
hydrogen iodide 2 h; Heating;
参考文献
D'Alcontres,S. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 203 - 209
