5-(4-溴苯基)-2-呋喃甲醛合成路线 （共 22 条）
反应条件
piperidine; pyridine
4 h; Heating;
参考文献
Obushak, N. D.; Ganushchak, N. I.; Lesyuk, A. I.; Dzikovskaya, L. M.; Kisilitsa, P. P.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 4 p. 748 - 753
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 4 p. 873 - 880
反应条件
1.1: sodium tetrahydroborate / methanol / 20 °C
2.1: thionyl chloride; benzotriazol-1-ol / dichloromethane
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
3.2: 20 - 60 °C
4.1: water; sodium hydroxide / methanol / 20 h / 20 °C
5.1: toluene / 2 h / Reflux
6.1: hydrogenchloride / 1,4-dioxane / 4 h / Reflux
7.1: phenylalanine ammonia-lyase / 192 h / 30 °C / pH 8.8 / aq. buffer; Inert atmosphere; Enzymatic reaction
View Scheme
参考文献
Paizs, Csaba; Tosa, Monica Ioana; Bencze, Laszlo Csaba; Brem, Juergen; Irimie, Florin Dan; Retey, Janos
Heterocycles, 2011 , vol. 82, # 2 p. 1217 - 1228
