1-[1,1'-联苯]-4-基-2-苯基乙-1-酮合成路线 （共 15 条）
反应条件
aluminium trichloride in 1,2-dichloro-ethane
参考文献
Shin, Steve H.; Cizmeciyan, Deniz; Keating, Amy E.; Khan, Saeed I.; Garcia-Garibay, Miguel A.
Journal of the American Chemical Society, 1997 , vol. 119, # 8 p. 1859 - 1868
反应条件
1: 4-bromo-1,1'-biphenyl With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N-methoxy-N-methyl-2-phenylacetamide in tetrahydrofuran T=-78°C; 2 h;
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
Location in patent: Page/Page column 140 ;
WO 2011/038204 A1
反应条件
phosphoric acid; trifluoroacetic anhydride in water T=25°C; 0.0166667 h;
参考文献
Veeramaneni, Venugopal Rao; Pal, Manojit; Yeleswarapu, Koteswar Rao
Tetrahedron, 2003 , vol. 59, # 18 p. 3283 - 3290
反应条件
[NiI2(PPh3)]; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=80°C; Kumada Cross-Coupling; Inert atmosphere;
参考文献
Wu, Ji-Cheng; Gong, Lu-Bing; Xia, Yuanzhi; Song, Ren-Jie; Xie, Ye-Xiang; Li, Jin-Heng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9909 - 9913
反应条件
Ni(PCy3)2Cl2; sodium t-butanolate in N,N-dimethyl-formamide; toluene T=100°C; Suzuki-Miyaura coupling; 0.666667 h; Inert atmosphere;
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
[NiI2(PPh3)]; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=80°C; Kumada Cross-Coupling; Inert atmosphere;
参考文献
Wu, Ji-Cheng; Gong, Lu-Bing; Xia, Yuanzhi; Song, Ren-Jie; Xie, Ye-Xiang; Li, Jin-Heng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9909 - 9913
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: Ni(PCy3)2Cl2; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 0.67 h / 100 °C / Inert atmosphere View Scheme
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
benzene nachfolgend Hydrolyse;
参考文献
Ferriss; Turner
Journal of the Chemical Society, 1920 , vol. 117, p. 1145
反应条件
sodium tetrahydroborate
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
反应条件
1: NaBH4
2: PBr3
3: (i) NaH, DMF, (ii) /BRN= 2117276/, (iii) aq. NaOH, EtOH
4: polyphosphoric acid / 160 - 170 °C
5: NaBH4
6: 160 - 170 °C
View Scheme
参考文献
Shadbolt; Woodward; Birchwood
Journal of the Chemical Society. Perkin transactions 1, 1976 , # 11 p. 1190 - 1195
