1: With hydrazine hydrate 5 h; Heating; 2: With potassium hydroxide in diethylene glycol T=160 - 220°C; Further stages.;

1.1: 73 percent / potassium hydroxide / ethanol / 20 °C 2.1: hydrazine hydrate / 5 h / Heating 2.2: 62 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 160 - 220 °C View Scheme

1.1: 45 percent / potassium acetate; acetic anhydride / 2 h / Heating 2.1: 73 percent / potassium hydroxide / ethanol / 20 °C 3.1: hydrazine hydrate / 5 h / Heating 3.2: 62 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 160 - 220 °C View Scheme

1.1: 72 percent / aq. KOH / Heating 2.1: 45 percent / potassium acetate; acetic anhydride / 2 h / Heating 3.1: 73 percent / potassium hydroxide / ethanol / 20 °C 4.1: hydrazine hydrate / 5 h / Heating 4.2: 62 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 160 - 220 °C View Scheme

1.1: 76 percent / triton B / 2-methyl-propan-2-ol / 1 h / 20 - 25 °C 2.1: 72 percent / aq. KOH / Heating 3.1: 45 percent / potassium acetate; acetic anhydride / 2 h / Heating 4.1: 73 percent / potassium hydroxide / ethanol / 20 °C 5.1: hydrazine hydrate / 5 h / Heating 5.2: 62 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 160 - 220 °C View Scheme

1-diethylamino-1,1-difluoro-2-chloro-2-fluoro-ethane T=130 - 140°C; 1 h;

phosphoric acid; sodium chloride T=100°C; 1 h;

1: HF, Py 2: Br2, CF3CO2Ag View Scheme

1: HF, Py 2: HNO3, Ac2O View Scheme

1: HF, Py 2: HNO3, Ac2O 3: H2 / PtO2 View Scheme