N-甲基-1-苯基-7,8-二甲氧基-2,3,4,5-四氢-3-苯并氮杂卓合成路线 （共 14 条）
反应条件
formic acid
4 h; Heating;
参考文献
Neumeyer; Kula; Baldessarini; Baindur
Journal of medicinal chemistry, 1992 , vol. 35, # 8 p. 1466 - 1471
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride in N,N-dimethyl-formamide
3 h; Ambient temperature; Yields of byproduct given;
参考文献
Sato, Yoshiro; Shirai, Naohiro; Machida, Yoshio; Ito, Emiko; Yasui, Takayo; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6711 - 6716
反应条件
1: 79 percent / K2CO3 / acetonitrile
2: 51 percent / H2SO4 / trifluoroacetic acid; CH2Cl2
3: 85 percent / HCOOH
View Scheme
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron Letters, 1989 , vol. 30, # 27 p. 3581 - 3584
反应条件
1: 51 percent / H2SO4 / trifluoroacetic acid; CH2Cl2
2: 85 percent / HCOOH
View Scheme
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron Letters, 1989 , vol. 30, # 27 p. 3581 - 3584
反应条件
1: 79 percent / K2CO3 / acetonitrile
2: 51 percent / H2SO4 / trifluoroacetic acid; CH2Cl2
3: 85 percent / HCOOH
View Scheme
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron Letters, 1989 , vol. 30, # 27 p. 3581 - 3584
反应条件
cesium fluoride in N,N-dimethyl-formamide
3 h; Ambient temperature;
参考文献
Sato, Yoshiro; Shirai, Naohiro; Machida, Yoshio; Ito, Emiko; Yasui, Takayo; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6711 - 6716
反应条件
1: SOCl2 / tetrahydrofuran / 1 h / Heating
2: K2CO3 / benzene; H2O / Ambient temperature
3: 530 mg / borane-THF / tetrahydrofuran / 0 deg C, then 1 h, reflux
4: 53 percent / Et3N / diethyl ether / 0.5 h / 0 °C
5: 70 percent / NaIO4 / H2O; methanol / 15 h / Ambient temperature
6: 70 percent / TFAA / CH2Cl2 / 20 h / Ambient temperature
7: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
8: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
反应条件
1: 530 mg / borane-THF / tetrahydrofuran / 0 deg C, then 1 h, reflux
2: 53 percent / Et3N / diethyl ether / 0.5 h / 0 °C
3: 70 percent / NaIO4 / H2O; methanol / 15 h / Ambient temperature
4: 70 percent / TFAA / CH2Cl2 / 20 h / Ambient temperature
5: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
6: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
反应条件
1: 70 percent / NaIO4 / H2O; methanol / 15 h / Ambient temperature
2: 70 percent / TFAA / CH2Cl2 / 20 h / Ambient temperature
3: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
4: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
反应条件
1: 70 percent / TFAA / CH2Cl2 / 20 h / Ambient temperature
2: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
3: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
